Susan M Domchek Selected Research

Biomarkers (Surrogate Marker)

1/2020	Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction.
1/2019	Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy.
11/2018	Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy.
3/2015	Breast MRI fibroglandular volume and parenchymal enhancement in BRCA1 and BRCA2 mutation carriers before and immediately after risk-reducing salpingo-oophorectomy.
9/2009	No evidence that GATA3 rs570613 SNP modifies breast cancer risk.

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Susan M Domchek Research Topics

Disease

75	Breast Neoplasms (Breast Cancer) 11/2022 - 11/2002
65	Neoplasms (Cancer) 01/2022 - 11/2002
25	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 03/2006
5	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2018
5	Disease Progression 01/2020 - 02/2016
4	Carcinogenesis 12/2011 - 02/2004
3	Fatigue 01/2022 - 08/2017
3	Triple Negative Breast Neoplasms 11/2021 - 01/2019
3	Genetic Risk Score 01/2021 - 01/2017
3	Stomach Neoplasms (Stomach Cancer) 01/2020 - 01/2019
3	Vomiting 11/2019 - 08/2017
3	Nausea 11/2019 - 08/2017
2	Prostatic Neoplasms (Prostate Cancer) 11/2022 - 01/2015
2	Second Primary Neoplasms (Neoplasms, Second) 01/2020 - 07/2011
2	Asthenia 11/2019 - 08/2017
2	Heart Failure 01/2019 - 05/2014
2	Carcinoma (Carcinomatosis) 08/2017 - 02/2004
1	Hypertension (High Blood Pressure) 01/2022
1	Cardiotoxicity 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2022
1	COVID-19 01/2022
1	Cysts 11/2021
1	Pain (Aches) 01/2021
1	Li-Fraumeni Syndrome 05/2020
1	Adenocarcinoma 01/2020
1	Chromosome Fragility 01/2019
1	Hot Flashes 01/2019
1	Neutropenia 01/2019
1	Anemia 08/2017

Drug/Important Bio-Agent (IBA)

21	Estrogen ReceptorsIBA 11/2022 - 09/2009
13	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021 - 07/2010
10	PlatinumIBA 01/2022 - 01/2015
10	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 12/2007
9	olaparibIBA 01/2021 - 07/2010
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
7	Hormones (Hormone)IBA 01/2019 - 07/2010
5	NucleotidesIBA 11/2022 - 04/2015
5	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 01/2011
5	Biomarkers (Surrogate Marker)IBA 01/2020 - 09/2009
4	rucaparibIBA 01/2021 - 08/2017
4	Telomerase (Telomerase Reverse Transcriptase)IBA 12/2007 - 02/2004
3	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2019
3	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2021 - 01/2014
3	human ERBB2 proteinIBA 01/2021 - 01/2020
3	Trastuzumab (Herceptin)FDA Link 01/2020 - 06/2003
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 09/2009
3	Biological ProductsIBA 01/2020 - 01/2016
3	AntigensIBA 06/2017 - 11/2005
3	Peptides (Polypeptides)IBA 12/2007 - 02/2004
2	CytokinesIBA 01/2022 - 07/2009
2	VaccinesIBA 01/2022 - 11/2007
2	Phenobarbital (Luminal)FDA Link 11/2021 - 01/2020
2	ORALIT (ORS)IBA 01/2021 - 12/2020
2	Poly Adenosine Diphosphate RiboseIBA 01/2021 - 10/2017
2	AnthracyclinesIBA 01/2020 - 01/2019
2	ErbB Receptors (EGF Receptor)IBA 10/2019 - 10/2017
2	Alanine Transaminase (SGPT)IBA 01/2019 - 08/2017
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2019 - 08/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 02/2017
2	Tamoxifen FDA LinkGeneric 01/2016 - 02/2003
2	Dihydrotachysterol (AT 10)IBA 05/2014 - 06/2010
2	Estrogens (Estrogen)FDA Link 10/2013 - 01/2011
2	telomerase reverse transcriptase (540-548)IBA 12/2007 - 02/2004
2	AutoantigensIBA 11/2005 - 02/2004
2	EnzymesIBA 11/2005 - 02/2004
1	NivolumabIBA 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	IpilimumabIBA 01/2022
1	Adenosine Monophosphate (AMP)IBA 01/2022
1	niraparibIBA 01/2022
1	CateninsIBA 01/2020
1	durvalumabIBA 01/2020
1	TabletsIBA 01/2020
1	Hemoglobins (Hemoglobin)IBA 11/2019
1	PerforinIBA 01/2019
1	diepoxybutaneIBA 01/2019
1	A-Form DNA (A-DNA)IBA 01/2019
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2019
1	pro-brain natriuretic peptide (1-76)IBA 01/2019
1	Retinoblastoma ProteinIBA 01/2019
1	acivicin (AT 125)IBA 01/2019
1	palbociclibIBA 01/2019
1	imidazole mustard (BIC)IBA 12/2018
1	PM 01183IBA 11/2018
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 06/2017
1	B7-H1 AntigenIBA 06/2017

Therapy/Procedure

28	Therapeutics 01/2022 - 06/2003
14	Drug Therapy (Chemotherapy) 01/2022 - 11/2002
14	Salpingo-oophorectomy 01/2021 - 03/2006
5	Mastectomy (Mammectomy) 01/2016 - 10/2009
5	Ovariectomy (Oophorectomy) 10/2009 - 02/2006
3	Immunotherapy 06/2017 - 02/2004
2	Adjuvant Chemotherapy 01/2021 - 04/2010
2	Radiotherapy 05/2020 - 07/2011
2	Adjuvant Radiotherapy 05/2020 - 06/2010
2	Gastrectomy 01/2020 - 01/2019
2	Prophylactic Mastectomy 12/2007 - 10/2007
2	Chemoprevention 10/2007 - 02/2003
1	Contraindications 05/2020
1	Intravenous Infusions 01/2020